OPTIMIZING GUT HEALTH WITH
POSTBIOTICS

Postbiotics have been identified as a promising area of human health innovation. In 2021, the International Scientific Association for Probiotics and Prebiotics (ISAPP) defined a postbiotic as "a preparation of inanimate microorganisms and/or their components that confers a health benefit on the host". However, most health practitioners aren’t yet using these new resources with their patients and clients.

Butyrate for Gut Health Issues and More

The short-chain fatty acid butyrate, which may be one of the most promising postbiotics for gut health, works directly on the colon, which makes up one-fifth of the length of the gastrointestinal tract and houses trillions of bacteria that protect our gut and produce vitamins.

Butyrate is one of the most important energy sources for enterocytes, as it helps to renew the intestinal epithelium and can also modulate gene expression by incompetently inhibiting histone deacetylases.

Enterocytes, or intestinal absorptive cells, are the epithelial cells that line the inner surface of the small and large intestines. They are responsible for absorbing all nutrients in the digestive tract. Yet their function may be disrupted in a wide range of patients or clients, such as those with intestinal inflammation, gut issues such as leaky gut, stress, anemia, immune system dysregulation, as well as many others.

In addition to its well-recognized role as the preferred energy source for colonocytes, butyrate has now been shown to have a much broader physiological role that extends beyond the colon, influencing systemic metabolic and immune function, as well as reducing intestinal permeability and inflammation.

Clinical benefits of butyrate include the following:

• Butyrate is the primary fuel for epithelial cells of the colon and helps maintain intestinal barrier integrity and reduce intestinal inflammation.
• Butyrate has been associated with multiple metabolic effects and may play a role in weight and glycemic control, as well as enhancing insulin resistance.

What is Tributyrin?

Tributyrin is a postbiotic that contains three butyrate moieties esterified with glycerol, and rapidly absorbed and hydrolyzed to butyrate when metabolized by pancreatic lipases.Multiple models suggest tributyrin protects the liver and intestinal barrier from a variety of insults, including ethanol and bacterial toxins. Found in honey and dairy products such as butter, tributyrin has several advantages in comparison to butyrate as a supplement, such as:

1. More bioavailable
2. Better tolerated
3. Allows for significantly higher plasma levels
4. Has approximately three times the serum half-life (demonstrated in animal studies)

Butyric Cal-Mag™ from Biotics Research is a supplement with nutrient synergists that can help support gut health. It supplies tributyrin as ButyraGen™, a butyrate generator. When it is broken down by gut enzymes, it supplies the postbiotic butyrate, along with complementary antioxidants in the form of mixed carotenoids (a source of vitamin A), as well as calcium and magnesium. Butyric Cal-Mag™ also provides pantothenic acid, necessary for the synthesis of acetyl CoA because inhibition of the acetyl CoA pathway has been associated with impaired butyrate synthesis.

For more information on Butyric Cal-Mag™ and to stay current in the field of postbiotics, you can try this product for yourself at https://shop.bioticsresearch.com/products/butyric-cal-mag

*This statement has not been evaluated by the Food and Drug Administration.This product is not intended to diagnose, treat, cure, or prevent any disease.