A randomized double blind clinical trial of children ages 3-6 recently released from the Agency for Health Care Policy and Research (AHCPR), concluded that "there was no benefit from amoxicillan prophylaxis compared to a placebo control in preventing new AOM (acute otitis media) episodes."
Free of AOM (%)
30-90 Days:
Placebo Group:71% Otitis Free
Daily Amoxicillan Group: 65% Otitis Free
Twice Daily Amoxicillan Group: 62% Otitis Free
3 Months or Longer:
Placebo Group:54% Otitis Free
Daily Amoxicillan Group: 63% Otitis Free
Twice Daily Amoxicillan Group: 60% Otitis Free
SOURCE: Berman S. Continuous twice daily or once daily amoxicillan prophylaxis compared to placebo for children with recurrent otitis media. Agency for Health Care Policy and Research grant no.: RO3 HS07283-02.
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